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Bupropion is unique and unlike other antidepressants in that its major effect is on dopamine, an effect that is not shared by the selective serotonin reuptake inhibitors or ssris for example, paroxetine paxil , fluoxetine prozac , sertraline zoloft or the tricyclic antidepressants or tcas for example, amitriptyline elavil, endep , imipramine tofranil , desipramine norpramin .

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in 2002 came the first reported case of psychosis in a young 29-year-old man treated with bupropion for smoking cessation.

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data from a comparative trial of the sustained-release formulation of bupropion hcl, nicotine transdermal system nts , the combination of sustained-release bupropion plus nts, and placebo as an aid to smoking cessation suggest a higher incidence of treatment-emergent hypertension in patients treated with the combination of sustained-release bupropion and nts.

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