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Metformin has been previously shown to inhibit mitochondrial complex i, yet it is not known whether metformin exhibits its anti-tumor effects through inhibition of complex i.

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andrzejewski s , gravel s-p , pollak m , st-pierre j 2014 metformin directly acts on mitochondria to alter cellular bioenergetics.

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metformin is often the first drug used for newly diagnosed type 2 diabetic patients and in 2006 it accounted for 37 of the noninsulin diabetes prescriptions in the united states.

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