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Tissue concentrations of allopurinol have not been reported in humans, but it is likely that allopurinol and oxipurinol will be present in the highest concentrations in the liver and intestinal mucosa where xanthine oxidase activity is high.

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Of the 37 patients randomized, two were excluded from the analysis, and of the remaining subjects, 31 completed the study 17 in the placebo and 14 in the allopurinol groups.

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